Product Name: KCNN3 antibody, C-term
Applications: IHC-P, WB
Predicted Target Size: 82 KDa (note)
Positive Controls: Daudi , mouse brain
Form Supplied: Liquid
Concentration: 0.5-1 mg/ml
Purification: Affinity Purified
Full Name: potassium calcium-activated channel subfamily N member 3
Background: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Synonyms: HSK3 Antibody , SK3 Antibody , KCNN3 Antibody , SKCA3 Antibody , KCA2.3 Antibody
Cellular Localization:
CAS NO: 7411-49-6
Product: Minaprine (dihydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: A synthetic peptide corresponding to a C-terminal region of Human KCNN3
Antigen Species: Human
Species Reactivity: Human, Mouse, Rhesus Monkey
Conjugation: Unconjugated
Storage Buffer: 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25356743?dopt=Abstract
