Product Name: KCNQ1 antibody, C-term
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: potassium voltage-gated channel, KQT-like subfamily, member 1
Background: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Synonyms: long (electrocardiographic) QT syndrome, WardRomano syndrome1, Kv1.9, LQT, WRS, RWS, Kv7.1, potassium voltage-gated, Jervell and LangeNielsen syndrome1, KCNQ1, KCNA8, KVLQT1, KCNA9, LQT1, long (electrocardiographic) QT syndrome, Ward-Romano syndrome 1, FLJ26167, kidney and cardiac voltage dependend K+ channel, potassium voltagegated, Jervell and LangeNielsen syndrome 1, ATFB1, ATFB3, JLNS1, SQT2, potassium voltage gated
Cellular Localization:
CAS NO: 894783-71-2
Product: Pazufloxacin (mesylate)
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-EQLTVPRRGPDEGS
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for KCNQ1.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24653979?dopt=Abstract
