Product Name: KCNQ2 antibody
Applications: ICC/IF, IHC-Fr, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity Purified
Full Name: potassium voltage-gated channel, KQT-like subfamily, member 2
Background: KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
Synonyms: KCNQ2, BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1, potassium voltage-gated channel, KQT-like subfamily, member 2
Cellular Localization:
CAS NO: 315704-66-6
Product: Azelaic acid
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: GST fusion protein encoding the first 70 amino acids of human KCNQ2.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: (1 mg/ml) in PBS containing 1 mg/ml BSA, glycerol, and 0.02% sodium azide.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24870145?dopt=Abstract
