Product Name: KCNQ2 antibody [S26A-23]
Applications: IHC, IHC-Fr, IP, WB
Predicted Target Size: 95kDa (note)
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G Purified
Full Name: potassium voltage-gated channel, KQT-like subfamily, member 2
Background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: KCNQ2, KV7.2, ENB1, voltage gated potassium channel subunit Kv7.2, KQT like2, BFNC, KCNA11, KVEBN1. KvLQT2, HNSPC, KQT like 2, EBN1
Cellular Localization:
CAS NO: 591778-68-6
Product: UK 14,304 (tartrate)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Fusion protein amino acids 1-59 of human KCNQ2, accession number O43526
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: PBS pH7.4, 50% glycerol
Storage Instruction: Aliquot and store at -20 C. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24982195?dopt=Abstract
