Product Name: KCNQ4 antibody [S43-6]
Applications: ICC/IF, IHC-Fr, IP, WB
Predicted Target Size: 77kDa (note)
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G Purified
Full Name: potassium voltage-gated channel, KQT-like subfamily, member 4
Background: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: KQT like4, DFNA2, KQT like 4, KCNQ4, Kv7.4, voltage gated potassium channel subunit Kv7.4
Cellular Localization: Situated at the basal membrane of cochlear outer hair cells.
CAS NO: 18378-20-6
Product: Mafenide (hydrochloride)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Fusion protein amino acids 2-77 of human KCNQ4, accession number P56696
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: PBS pH7.4, 50% glycerol
Storage Instruction: Aliquot and store at -20 C. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23767827?dopt=Abstract
