Product Name: KCNQ5 antibody
Applications: IHC, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity Purified
Full Name: potassium voltage-gated channel, subfamily Q, member 5-like
Background: KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.
Synonyms: Kcnq5l, Kcnq5, potassium voltage-gated channel, subfamily Q, member 5-like
Cellular Localization:
CAS NO: 82611-85-6
Product: L-(-)-α-Methyldopa (hydrate)
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: Synthetic peptide corresponding to residues C(880) K A G E S T D A L S L P H V K L K(897) of human KCNQ5 protein.
Antigen Species: Rat
Species Reactivity: Human, Rat
Conjugation: Unconjugated
Storage Buffer: PBS containing 1 mg/ml BSA and 0.05% sodium azide.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23653383?dopt=Abstract
