Product Name: KIR2DL3 antibody [8P9]
Applications: FACS
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: The IgG fraction of culture supernatant was purified by Protein G affinity chromatography
Full Name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several “framework” genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
Synonyms: KIR-K7b Antibody , NKAT2 Antibody , killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 Antibody , CD158B2 Antibody , CD158b Antibody , p58 Antibody , NKAT Antibody , NKAT2B Antibody , GL183 Antibody , NKAT2A Antibody , KIRCL23 Antibody , KIR-K7c Antibody , KIR-023GB Antibody
Cellular Localization:
CAS NO: 185991-07-5
Product: APY0201
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2
Immunogen: Human recombinant KIR2DL3
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody was selected for its ability to specifically detect human KIR2DL3.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22982396?dopt=Abstract
