Product Name: KIR3DL1 antibody
Applications: WB
Predicted Target Size: 49 kDa (note) (2)
Positive Controls: A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several “framework” genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq]
Synonyms: CD158E1 antibody, KIR antibody, KIR3DL1/S1 antibody, MGC119726 antibody, MGC119728 antibody, MGC126589 antibody, MGC126591 antibody, NKAT3 antibody, NKB1 antibody, NKB1B antibody, KIR3DL1 antibody, CD158 antigen-like family member E antibody, MHC class I NK cell receptor antibody, killer Ig receptor antibody, natural killer-associated transcript 3 antibody, KIR antigen 3DL1 antibody, p70 natural killer cell receptor clones CL-2/CL-11 antibody, NKAT-3 antibody, NK-receptor antibody, p70 NK receptor CL-2/CL-11 antibody, killer cell immunoglobulin-like receptor 3DL1 antibody, HLA-BW4-specific inhibitory NK cell receptor antibody, p70 killer cell inhibitory receptor antibody, “killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 antibody”
Cellular Localization: Cell membrane; Single-pass type I membrane protein
CAS NO: 935888-69-0
Product: Mebeverine metabolite O-desmethyl Mebeverine alcohol
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human KIR3DL1. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27487076?dopt=Abstract
