Product Name: KPNA2 antibody [C3], C-term
Applications: ICC/IF, IHC-P, WB
Predicted Target Size: 58 kDa (note) (2)
Positive Controls: 293T , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji
Form Supplied: Liquid
Concentration: 0.71 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Background: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq]
Synonyms: IPOA1 antibody, QIP2 antibody, RCH1 antibody, SRP1alpha antibody, KPNA2 antibody, karyopherin subunit alpha-2 antibody, SRP1-alpha antibody, RAG cohort 1 antibody, importin alpha 1 antibody, importin subunit alpha-2 antibody, RAG cohort protein 1 antibody, pendulin antibody, importin-alpha-P1 antibody, importin alpha 2 antibody, “karyopherin alpha 2 (RAG cohort 1, importin alpha 1) antibody”
Cellular Localization: Cytoplasm , Nucleus
CAS NO: 68-22-4
Product: GSK2879552
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human KPNA2. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19327736?dopt=Abstract
