Product Name: KPNA2 antibody, C-term
Applications: ICC/IF, WB
Predicted Target Size:
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX26036-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Background: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.
Synonyms: RCH1, RAG cohort 1, karyopherin alpha 2 (RAG cohort 1, importin alpha 1), KPNA2, importin alpha 1, importin alpha1, KPNA2 / IPOA1, importinalphaP1, SRP1alpha, IPOA1 QIP2, RAG cohort1, karyopherin alpha 2, importin alpha2, pendulin, karyopherin alpha2 (RAG cohort1, importin alpha1), karyopherin alpha2, importin alpha 2, importin-alpha-P1, IPOA1, QIP2, importin alpha P1
Cellular Localization:
CAS NO: 939791-38-5
Product: ORY-1001
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-QVQDGAPGTFNF
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for KPNA2.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19152798?dopt=Abstract
