Product Name: KPNA3 antibody, C-term
Applications: ICC/IF, IHC-P, IP, WB
Predicted Target Size:
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX26038-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: karyopherin alpha 3 (importin alpha 4)
Background: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.
Synonyms: RP11432M24.3, SRP4, importin alpha3, hSRP1, importin alpha4, KPNA3 / IPOA4, importin alpha 4, SRP1, karyopherin alpha3, IPOA4, importin alpha-3, importinalphaQ2, RP11-432M24.3, karyopherin alpha3 (importin alpha4), karyopherin alpha 3, SRP1gamma, KPNA3, importin-alpha-Q2, karyopherin alpha 3 (importin alpha 4), importin alpha 3, importin alpha Q2
Cellular Localization: Cytoplasmic and Nuclear
CAS NO: 554-57-4
Product: Decernotinib
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-DPTANLQTKEFNF
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for KPNA3.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19049346?dopt=Abstract
