Product Name: KRIT1 antibody [C1C3]
Applications: EM, WB
Predicted Target Size: 84 kDa (note) (34)
Positive Controls: 293T , A431 , Jurkat , Raji
Form Supplied: Liquid
Concentration: 0.74 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: KRIT1, ankyrin repeat containing
Background: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
Synonyms: CAM antibody, CCM1 antibody, KRIT1 antibody, cerebral cavernous malformations 1 protein antibody, krev interaction trapped protein 1 antibody, ankyrin repeat-containing protein Krit1 antibody, krev interaction trapped 1 antibody, “KRIT1, ankyrin repeat containing antibody”
Cellular Localization: Membrane; Peripheral membrane protein
CAS NO: 329-56-6
Product: LY2409881
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human KRIT1. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18460596?dopt=Abstract
