Product Name: Ku70 + Ku80 antibody [162]
Applications: EMSA, FACS, ICC/IF, IHC-P, IP, WB, RIP
Predicted Target Size:
Positive Controls: HeLa cells. Tonsil.
Form Supplied: Liquid
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by ammonium sulfate precipitation.
Full Name:
Background: The Ku autoantigen is a heterodimer of 70 kDa (p70) and ~80 kDa (p80) proteins. The p70 / p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Synonyms: CTC75, FLJ39089, CTCBF, KARP-1, G22P1, KARP1, KU70, KU80, ML8, KUB2, TLAA, Ku86, NFIV, KARP 1
Cellular Localization: Nuclear.
CAS NO: 39562-70-4
Product: GNE-317
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2a
Immunogen: Human B cell nuclei from plasmacytoid 2p68 cells.
Antigen Species: Human
Species Reactivity: Human, Mouse, Monkey, Rat, Xenopus laevis
Conjugation: Unconjugated
Storage Buffer: 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/16723499?dopt=Abstract
