Product Name: Ku70 antibody [529]
Applications: ICC/IF, WB
Predicted Target Size: 70 kDa (note)
Positive Controls: Jurkat , Raji , 293T , A431 , HeLa , HepG2 , H1299 , HCT116 , MCF-7 , NT2D1 , PC-3 , U87-MG
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Background: Originally identified as an autoantigen, the Ku protein are nuclear proteins found in eukaryotes. They exist as a heterodimer consisiting of Ku 70 and Ku 80, migrating at approximately 70 and 80 kDa respectively. They bind to DNA ends at double strand breaks. The Ku proteins interact with the DNA-dependent protein kinase (DNA-PK) and participate in the targeting of DNA-PK to DNA. The Ku proteins may participate in numerous cellular processes, including DNA repair and replication, cell signalling, cell proliferation, transcriptional activation and apoptosis.
Synonyms: CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Cellular Localization:
CAS NO: 24280-93-1
Product: ML228
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Immunogen: Recombinant antigen containing the amino terminal portion of human Ku70 protein
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Phosphate-buffered saline, pH 7.2, containing no preservatives
Storage Instruction: Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/16200211?dopt=Abstract
