Product Name: Ku70 antibody [N1N3]
Applications: ICC/IF, IHC-P, WB
Predicted Target Size: 70 kDa (note) (3)
Positive Controls: 293T , A431 , Jurkat , Raji
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Background: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq]
Synonyms: CTC75 antibody, CTCBF antibody, G22P1 antibody, KU70 antibody, ML8 antibody, TLAA antibody, XRCC6 antibody, CTC box-binding factor 75 kDa subunit antibody, “ATP-dependent DNA helicase II, 70 kDa subunit antibody”, ATP-dependent DNA helicase II 70 kDa subunit antibody, X-ray repair cross-complementing protein 6 antibody, ATP-dependent DNA helicase 2 subunit 1 antibody, lupus Ku autoantigen protein p70 antibody, thyroid autoantigen 70kD (Ku antigen) antibody, 5-deoxyribose-5-phosphate lyase Ku70 antibody, “Ku autoantigen, 70kDa antibody”, DNA repair protein XRCC6 antibody, thyroid-lupus autoantigen p70 antibody, thyroid autoantigen 70kDa (Ku antigen) antibody, CTC box binding factor 75 kDa subunit antibody, 70 kDa subunit of Ku antigen antibody, 5-dRP lyase Ku70 antibody, Ku autoantigen p70 subunit antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 antibody
Cellular Localization: Nucleus
CAS NO: 3160-91-6
Product: Genz-123346 (free base)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human Ku70. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/14691259?dopt=Abstract
