Product Name: Ku70 antibody [N3H10]
Applications: ICC/IF, IHC-P, IP, WB
Predicted Target Size:
Positive Controls: BT474, HEP-G-2 or HeLa cells. Tonsil tissue sections.
Form Supplied: Liquid
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A purified
Full Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Background: The Ku autoantigen is a heterodimer of 70 kDa (p70) and ~80 kDa (p80) proteins. The p70 / p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Synonyms: CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Cellular Localization: Nuclear
CAS NO: 70476-82-3
Product: Genz-123346
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Immunogen: Human placental extract designated as PSE1-PL.
Antigen Species: Human
Species Reactivity: Human, Mouse, Monkey, Hamster, Xenopus laevis
Conjugation: Unconjugated
Storage Buffer: 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27406709?dopt=Abstract
