Product Name: Ku80 antibody
Applications: ELISA, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified IgG
Full Name:
Background: Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.
Synonyms:
Cellular Localization:
CAS NO: 89226-50-6
Product: K-7174
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen:
Antigen Species:
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: PBS containing 0.02% sodium azide.
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Reacts with residues 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein. Sequence is 100% conserved between human, mouse rat and hamster.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26104798?dopt=Abstract
