Product Name: LAMP1 antibody [B-T47]
Applications: FACS, ICC/IF, IHC-P
Predicted Target Size:
Positive Controls:
Form Supplied:
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Purification:
Full Name: lysosomal-associated membrane protein 1
Background: CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.Entrez Gene: 13q34
Synonyms: CD107a, LAMPA, LGP120, LAMP1, LAMP-1
Cellular Localization: This protein shuttles between lysosomes, endosomes, and the plasma membrane.
CAS NO: 987-65-5
Product: (S)-(-)-5-Fluorowillardiine
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: U937 human Caucasian hystiocytic lymphoma cell line
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized.
Storage Instruction: Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody B-T47 recognizes CD107a, a 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27045525?dopt=Abstract
