Product Name: LAMP1 antibody [LY1C6]
Applications: ICC/IF, IHC, IP, WB
Predicted Target Size:
Positive Controls: Highly purified rat lysosomal membrane preparations
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein G purified
Full Name: lysosomal-associated membrane protein 1
Background: Lysosome associated membrane proteins (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMC to the site of inflammation.
Synonyms: LGP120
Cellular Localization: Type I membrane protein. Lysosomal. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
CAS NO: 91296-87-6
Product: Methoxy-PEPy
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: This antibody was derived from mice that were immunized with rat liver lysosome membranes as the source of the full length LAMP1 protein.
Antigen Species: Rat
Species Reactivity: Human, Mouse, Rat, Hamster
Conjugation: Unconjugated
Storage Buffer: Preservative: NoneConstituents: 50% Glycerol, PBS, 0.1mM PMSF. pH 7.2
Storage Instruction: Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27122586?dopt=Abstract
