Product Name: LAT1 / SLC7A5 antibody, Internal
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Background: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
Synonyms: Ltype amino acid transporter1, LAT1 / SLC7A5, large neutral amino acids transporter1, L-type amino acid transporter 1, large neutral amino acids transporter small subunit, D16S469E, Ltype amino acid transporter 1, large neutral amino acids transporter 1, sodiumindependent neutral amino acid transporter LAT1, sodium-independent neutral amino acid transporter LAT1, CD98, CD98 light chain, 4F2LC, E16, LAT1, MPE16, hLAT1
Cellular Localization: Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells.
CAS NO: 22033-87-0
Product: PF-06447475
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-RHRKPELERPIKVN
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for LAT1 / SLC7A5.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18765295?dopt=Abstract
