Product Name: LATS2 antibody
Applications: ELISA, ICC/IF, IHC-P
Predicted Target Size: 120 kDa (note)
Positive Controls:
Form Supplied:
Concentration:
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Full Name: LATS, large tumor suppressor, homolog 2 (Drosophila)
Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
Synonyms: LATS2, EC2.7.11.1, Serine/threonineprotein kinase kpm, Wartslike kinase, Large tumor suppressor homolog 2, Warts-like kinase, Large tumor suppressor homolog2, Serine/threonine-protein kinase kpm, EC 2.7.11.1, Kinase phosphorylated during mitosis protein, Warts like kinase
Cellular Localization: Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
CAS NO: 637-07-0
Product: Apoptosis Activator 2
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: The antiserum was produced against synthesized peptide derived from human LATS2.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Store at -20 degrees Celcius. Product is stable for at least 1 year.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: LATS2 Antibody detects endogenous levels of total LATS2 protein.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18316077?dopt=Abstract
