Product Name: LAT antibody [LAT-1D1]
Applications: EM, ICC/IF, IP, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification:
Full Name: linker for activation of T cells
Background: LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation. Entrez Gene (mouse): 7 F3Entrez Gene (rat): 1q36
Synonyms:
Cellular Localization: Present in lipid rafts.
CAS NO: 1338466-77-5
Product: Chidamide
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2a
Immunogen: Bacterially expressed full-length rat LAT
Antigen Species: Rat
Species Reactivity: Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Instruction: Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody LAT-1D1 reacts with mouse and rat Linker for activation of T cells (LAT), a transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19700766?dopt=Abstract
