Product Name: LAT (phospho Tyr132) antibody
Applications: ICC/IF, WB
Predicted Target Size:
Positive Controls: Jurkat E6.1 cells
Form Supplied:
Concentration: 0.35 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Immunogen affinity purified
Full Name: linker for activation of T cells
Background: Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosine phosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 132 mediates LAT binding to PLCgamma-1, and is necessary for TCR-mediated calcium mobilization and activation of ERK and NFAT proteins.
Synonyms: LAT1, pp36, LAT (phospho Y132), LAT (phospho Tyr132), LAT (pY132), LAT (pTyr132), LAT phospho Y132, LAT phospho Tyr132, Phospho LAT (Y132), Phospho LAT (Tyr132), Phospho LAT (pY132), Phospho LAT (pTyr132)
Cellular Localization: Cell Membrane
CAS NO: 14976-57-9
Product: C75 (trans)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic phospho peptide (Human) derived from a region of LAT that contains tyrosine 132.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.05% Sodium Azide; Constituents: PBS, 1mg/ml BSA. pH 7.3
Storage Instruction: Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20508036?dopt=Abstract
