Product Name: LDL Receptor antibody [15C8]
Applications: ELISA, FACS, ICC/IF, IHC-Fr, IP, WB
Predicted Target Size:
Positive Controls: Liver sections, HT1080 cells, HepG2 cells – Negative controls: HepG2 cells and normal skin
Form Supplied: Liquid
Concentration: 0.1 mg/ml (Please refer to the vial label for the specific concentration)
Purification:
Full Name:
Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Synonyms:
Cellular Localization: Cell Membrane and Cytoplasmic
CAS NO: 884-39-9
Product: Vinflunine (Tartrate)
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2a
Immunogen: A trypic digest of low density lipoprotein receptor from bovine
Antigen Species: Bovine
Species Reactivity: Human, Bovine
Conjugation: Unconjugated
Storage Buffer: 0.05M sodium phosphate containing 0.2% gelatin and 0.1% sodium azide
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20870728?dopt=Abstract
