Product Name: LIN7A antibody [GT377]
Applications: ICC/IF, WB
Predicted Target Size: 26 kDa (note) (2)
Positive Controls: MCF-7 , MDA-MB-231
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Affinity purified by Protein G.
Full Name: lin-7 homolog A (C. elegans)
Background: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Synonyms: VELI1 Antibody , TIP-33 Antibody , LIN-7A Antibody , lin-7 homolog A (C. elegans) Antibody , LIN7 Antibody , MALS-1 Antibody
Cellular Localization: Cell membrane; Peripheral membrane protein , Basolateral cell membrane; Peripheral membrane protein , Cell junction (By similarity) , Cell junction , synapse , postsynaptic cell membrane , postsynaptic density; Peripheral membrane protein (By similarity)
CAS NO: 476-66-4
Product: LY310762
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Immunogen: Recombinant protein encompassing a sequence within the center region of human LIN7A. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23426143?dopt=Abstract
