Product Name: LIN7B antibody, N-term
Applications: WB
Predicted Target Size:
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX25967-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: lin-7 homolog B (C. elegans)
Background: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
Synonyms: lin7 homolog B, LIN7B, Lin-7b protein likely ortholog of mouse LIN-7B mammalian LIN-7 protein 2, V, lin7 homolog B (C. elegans), Lin7b protein likely ortholog of mouse LIN7B mammalian LIN7 protein2, Lin7b protein likely ortholog of mouse LIN7B mammalian LIN7 protein 2, LIN-7B, LIN7B / MALS2, MALS-2, lin-7 homolog B, MALS2, VELI2, LIN 7B, MALS 2, lin 7 homolog B
Cellular Localization: Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.
CAS NO: 81403-68-1
Product: Saxagliptin (hydrate)
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: AALVEPLGLERDVS-C
Antigen Species: Human
Species Reactivity: Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for LIN7B / MALS-2.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27401144?dopt=Abstract
