Product Name: Laforin antibody, Internal
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Background: Dual specificity protein phosphatase. May be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS).
Synonyms: MELF, epilepsy, progressive myoclonus type 2A, Lafora disease (laforin), EPM2A, epilepsy, progressive myoclonus type 2, Lafora disease (laforin), EPM2, epilepsy, progressive myoclonus type2A, Lafora disease (laforin), laforin, epilepsy, progressive myoclonus type2, Lafora disease (laforin), Laforin (isoform a)
Cellular Localization: Under glycogenolytic conditions localizes to the nucleus. Primarily associated with polyribosomes at the endoplasmic reticulum, also found at the plasma membrane. Also found in the nucleus.
CAS NO: 42461-84-7
Product: Tipifarnib (S enantiomer)
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-EATGHTNEMKHTTD
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for Laforin (isoform a).
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25046439?dopt=Abstract
