Product Name: Lamin A antibody [JOL4]
Applications: ICC/IF, IHC-Fr, IP, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Unpurified
Full Name: lamin A/C
Background: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.
Synonyms: k66d12, LMN1, 70 kDa lamin, cb948, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL,
Cellular Localization: Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localiza
CAS NO: 50-42-0
Product: Indirubin
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Immunogen: Recombinant human lamin A
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tissue culture supernatant containing 0.2M Tris/HCl pH7.4 and 510% foetal calf serum
Storage Instruction: Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody reacts with both recombinant and native lamin A in humans, binding to an epitope between amino acids 572-646
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23946498?dopt=Abstract
