Product Name: Lamin A (cleaved Asp230) antibody
Applications: ELISA, IHC-P, WB
Predicted Target Size: 50 kDa (note)
Positive Controls:
Form Supplied:
Concentration:
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Full Name: lamin A/C
Background: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Synonyms: LAMA, Lamin A, 70 kDa lamin, LMN1, LMNA, Lamin A (cleaved D230), Lamin A (cleaved Asp230), Lamin A cleaved D230, Lamin A cleaved Asp230, Cleaved Lamin A (D230), Cleaved Lamin A (Asp230)
Cellular Localization: Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localiza
CAS NO: 936563-87-0
Product: NS-304
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: The antiserum was produced against synthesized peptide derived from human Lamin A.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Store at -20 degrees Celcius. Product is stable for at least 1 year.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Lamin A (Cleaved-Asp230) Antibody detects endogenous levels of fragment of activated Lamin A resulting from cleavage adjacent to Asp230.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24267262?dopt=Abstract
