Product Name: Lamin B antibody [X223]
Applications: ICC/IF, WB
Predicted Target Size: 65 – 67 kDa (note)
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: Unpurified
Full Name: lamin B1
Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq]
Synonyms: Lamin-L(I), MGC52550, lamin-b, lamin b, Lamin L(I), laminb, LaminL(I)
Cellular Localization:
CAS NO: 19392
Product: Bisdemethoxycurcumin
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Nuclear pore complex-lamina fraction of Xenopus laevis (XLKE-A6 cells)
Antigen Species: Xenopus laevis
Species Reactivity: Human, Mouse, Rat, Bovine
Conjugation: Unconjugated
Storage Buffer: Tissue culture supernatant containing 0.09% sodium azide
Storage Instruction: Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody decorates the karyoskeleton, i.e. the intermediate filament equivalent of the nucleus. Reacts with lamin isotypes of Mr 60 -75 kD. Recognises lamin B1 & B2 in human, bovine & rat, and lamin B2 in mouse
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22555058?dopt=Abstract
