Product Name: Lamin C antibody [EM-11]
Applications: ICC/IF, IP, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification:
Full Name: lamin A/C
Background: Lamin C is intermediate filament protein localized to the inner nuclear membrane. It is expressed predominantly in terminally differentiated cells and defines the shape and stability of nuclei in mammalian cells. Besides their structural roles, lamin proteins also regulate fundamental aspects of nuclear function and they cross-talk with cell signaling cascades and cell metabolism. Mutations of LMNA gene, encoding lamin A and C proteins, are often associated with pathogenesis of respective cell types, such as of heart myocytes.Entrez Gene (human): 1q21.2-q21.3
Synonyms: CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Cellular Localization: Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localiza
CAS NO: 969-33-5
Product: PF-06380101
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2a
Immunogen:
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Instruction: Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The mouse monoclonal antibody EM-11 recognizes lamin C, intermediate filament protein of nuclear lamina.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21847360?dopt=Abstract
