Product Name: Lck (phospho Ser158) antibody
Applications: WB
Predicted Target Size:
Positive Controls: Full length untagged recombinant human Lck protein
Form Supplied: Liquid
Concentration:
Purification: Immunogen affinity purified
Full Name: lymphocyte-specific protein tyrosine kinase
Background: Lck (p56lck), a member of the Src family of non-receptor tyrosine protein kinases, is expressed predominantly in T cells. Lck function is critical both for T cell development in the thymus and activation of mature T cells in the periphery by antigen. The activity of Lck is known to be regulated by phosphorylation of two conserved tyrosine residues, Tyr-505 (equivalent to Tyr-529 in c-Src) and Tyr-394 (equivalent to Tyr-418 in c-Src). The effects of phosphorylation at Ser-158 are still under investigation.
Synonyms: LSK, YT16, p56lck, pp58lck, Lck (phospho S158), Lck (phospho Ser158), Lck (pS158), Lck (pSer158), Lck phospho S158, Lck phospho Ser158, Phospho Lck (S158), Phospho Lck (Ser158), Phospho Lck (pS158), Phospho Lck (pSer158)
Cellular Localization: Cytoplasmic
CAS NO: 77-36-1
Product: PIK-294
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide (Human) derived from the region of Lck that contains serine 158 (based on Swiss Protein database, accession number P06239). The sequence is conserved in human and mouse.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.05% Sodium Azide; Constituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.4
Storage Instruction: Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21808067?dopt=Abstract
