Product Name: Lck (phospho Tyr192) antibody
Applications: WB
Predicted Target Size:
Positive Controls: Full length untagged recombinant human Lck protein
Form Supplied: Liquid
Concentration:
Purification: Immunogen affinity purified
Full Name: lymphocyte-specific protein tyrosine kinase
Background: Lck (p56lck), a member of the Src family of non-receptor tyrosine protein kinases, is expressed predominantly in T cells. Lck function is critical both for T cell development in the thymus and activation of mature T cells in the periphery by antigen. The activity of Lck is regulated by phosphorylation of multiple sites, including the two conserved tyrosine residues, Tyr-505 (equivalent to Tyr-529 in c-Src) and Tyr-394 (equivalent to Tyr-418 in c-Src). Phosphorylation of Lck Tyr-192 blocks high affinity binding of other proteins to the SH2 domain of Lck, thereby negatively regulating its participation in T cell antigen receptor signalling.
Synonyms: LSK, YT16, p56lck, pp58lck, Lck (phospho Y192), Lck (phospho Tyr192), Lck (pY192), Lck (pTyr192), Lck phospho Y192, Lck phospho Tyr192, Phospho Lck (Y192), Phospho Lck (Tyr192), Phospho Lck (pY192), Phospho Lck (pTyr192)
Cellular Localization: Cytoplasmic
CAS NO: 1206161-97-8
Product: Ro 48-8071 (fumarate)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide (Human) derived from the region of human Lck that contains tyrosine 192 (based on Swiss Protein database, accession number P06239). The sequence is conserved in human and mouse.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: Preservative: 0.05% Sodium Azide; Constituents: PBS, 50% glycerol, 1mg/ml BSA (IgG, protease free). pH 7.4
Storage Instruction: Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Lck (79% homologous), Hck (79% homologous) and Lyn (93% homologous) have not been tested.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20016070?dopt=Abstract
