Product Name: Leptin antibody [4F8]
Applications: ELISA
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1.8 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Protein A purified
Full Name:
Background: Leptin (from the Greek leptos, meaning thin) is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. The protein is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. Leptins effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure.
Synonyms:
Cellular Localization: Secreted
CAS NO: 1446144-04-2
Product: K-115
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen: Recombinant full length protein.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. We recommend to parafilm vials during storage to prevent evaporation of buffer.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody recognizes recombinant human leptin and leptin circulating in human blood.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26063870?dopt=Abstract
