Product Name: Lime1 antibody, C-term
Applications: WB
Predicted Target Size:
Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX17025-PEP).
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: Lck interacting transmembrane adaptor 1
Background: LIME (Lck-interacting molecule) is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation.
Synonyms: Lime1 (mouse), Lime1, LIME, Lck interacting transmembrane adaptor 1, RP2360M5.4, OTTMUSP00000018005, RIKEN cDNA2810038K19 gene, RP23-60M5.4, RIKEN cDNA 2810038K19 gene, 2810038K19Rik, Lck interacting transmembrane adaptor1
Cellular Localization:
CAS NO: 69004-03-1
Product: BX471
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-ENVYESIKEMGL
Antigen Species: Mouse
Species Reactivity: Mouse
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for Lime1 (mouse).
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26039975?dopt=Abstract
