Product Name: Livin antibody
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied:
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Immunogen affinity purified
Full Name: baculoviral IAP repeat containing 7
Background: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin / XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin alpha and Livin beta. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP 3 and DR6. Livin has direct interaction with several caspases including caspase 3, 7, and 9. Livin inhibits the activation of caspase 9 induced by Apaf 1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
Synonyms: 605737, Q96CA5, LIVIN, 79444, ML-IAP, MLIAP, BIRC7, KIAP, RNF50, ML IAP
Cellular Localization:
CAS NO: 54301-15-4
Product: CFTR(inh)-172
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide: CRAPVRSRVRTFLS, corresponding to amino acids 264 – 280 (short form) or 281 – 298 (long form) of Human Livin.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: PBS with 0.02% sodium azide
Storage Instruction:
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Detects both the alpha and beta (short and long) isoforms of Livin.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25386906?dopt=Abstract
