Product Name: eIF2 alpha (phospho Ser51) antibody
Applications: IHC-P, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration:
Purification: The antibody was purified by immunogen affinity chromatography.
Full Name: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Background: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Synonyms: EIF2A Antibody , EIF2 Antibody , EIF-2 Antibody , EIF-2A Antibody , EIF-2alpha Antibody , EIF2S1 Antibody , eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa Antibody
Cellular Localization:
CAS NO: 38647-11-9
Product: Flumazenil
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human EIF2S1. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Rat
Conjugation: Unconjugated
Storage Buffer: Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.
Storage Instruction: Shipped at 4 °C. Upon delivery aliquot and store at -20 °C for one year. Avoid freeze/thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Recognizes endogenous levels of EIF2S1 (pS51) protein.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22952573?dopt=Abstract
