Product Name: eIF3e antibody
Applications: ELISA, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.8 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: eukaryotic translation initiation factor 3, subunit E
Background: Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eIF3 translation initiation complex.There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stress-responsive genes. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth.
Synonyms: EIF3P46 Antibody , EIF3E Antibody , EIF3P48 Antibody , EIF3S6 Antibody , INT6 Antibody , 48KDA Antibody
Cellular Localization:
CAS NO: 627908-92-3
Product: PKI-587
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminus of mouse eIF3e.
Antigen Species: Mouse
Species Reactivity: Human, Mouse, Dog, Monkey, Rat, Bovine
Conjugation: Unconjugated
Storage Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 and 0.01% (w/v) Sodium Azide
Storage Instruction: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22076157?dopt=Abstract
