Product Name: eIF5A antibody, Internal (near N-term)
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: eukaryotic translation initiation factor 5A
Background: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of TP53/p53 and TP53/p53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Synonyms: EIF5A, EIF-5A, OTTHUMP00000128384, uORF A, eukaryotic translation initiation factor5A, MGC99547, eIF5AI, MGC104255, eukaryotic translation initiation factor 5A, EIF5A1, EIF 5A
Cellular Localization: Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
CAS NO: 477600-75-2
Product: PI3K inhibitor X
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-RPPHRASFLKRLESK
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for eIF5A.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20585375?dopt=Abstract
