Product Name: l Afadin antibody
Applications: ICC/IF, IHC-Fr, WB
Predicted Target Size:
Positive Controls: MDCK, HepG2, mouse liver, rat brain
Form Supplied:
Concentration:
Purification: Purified by affinity chromatography
Full Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
Background: Afadin is a cell-cell adherens junction F-actin binding multidomain protein. Two splice variants of afadin have been described: l-afadin, which is ubiquitously expressed, and the smaller s-afadin, which is abundantly expressed in neural tissue. l-Afadin contains one PDZ domain near its middle followed by three proline-rich and one F-actin-binding region at the carboxyl-terminal. l/s-Afadin is localized to cell-cell junctions and binds several cytoplasmic proteins such as the small GTPase Ras, the tight junction protein ZO-1, and the vinculin binding protein ponsin/SH3P12.
Synonyms: Af6
Cellular Localization:
CAS NO: 329-65-7
Product: Prinaberel
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide sequence corresponding to amino acid residues 1814-1829 of rat afadin with N-terminal cysteine conjugated to maleimide-activated KLH.
Antigen Species: Rat
Species Reactivity: Human, Mouse, Dog, Rat
Conjugation: Unconjugated
Storage Buffer: 0.01M PBS pH7.4, 1% BSA, 15 mM sodium azide
Storage Instruction: Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27268264?dopt=Abstract
