Diagnosis and the quality of the received treatment14. Hence the dearth of information regarding the determinants of mortality among PLWHA in China called for a detailed retrospective national level investigation to assess the impact of HIV on adult mortality and to identify correlates of total and AIDS-related mortality among adult PLWHA in this country. Our study aimed to evaluate the mortality rate among PLWHA since they were identified/reported and to evaluate the potential correlates of AIDS related and unrelated deaths in this population in China, by analyzing the data from a concurrent cohort study (The National HIV Epidemiology Cohort) which was monitoring mortality among PLWHA in China.MethodThe data used in this current article were obtained from the HIV/AIDS case reporting system (CRS) under the National Center for AIDS/STD Control and Prevention of the Chinese Center for Disease Control and Prevention (China CDC) between 1989 and 2013. The methods were carried out in accordance with the approved guidelines.Recruitment.Detailed information regarding the relevant databases is described elsewhere15. In brief, this retrospective cohort study was based on Chinese HIV/AIDS case report system and SIS3 biological activity treatment database. Any information collected from these two platforms was included in the current study base, while the two systems were linked by a unique personal ID. No additional identification information was collected from the participants. All newly identified HIV cases were reported to the web-based systems either by local hospitals or clinics. Information on demographic characteristics [age, gender, occupation, ethnicity, address, registered place of residency (Hukou) etc.], HIV related risk-behaviors, treatment history, routes of transmission (heterosexual/homosexual/IDU/transfusion of blood or other blood cells) and disease status (HIV/AIDS based on WHO criteria) at the time of diagnosis were also collected from all the registered PLWHA. PLWHA were considered eligible to be recruited for this concurrent cohort study if they were aged 18 years or older and had at least one follow up record since their initial reporting to the national database between January 1, 1989 and June 30, 2012. Frequency of CD4 testing for each participant was also calculated in every six months, and frequency of CD4 testing was defined as the cumulative number of CD4 testing at each year divided by two (every six months).After identification and reporting, all HIV cases were followed up by the local CDCs. The intervals of two follow up varied between three or six months, buy Tirabrutinib depending on the disease status. If already been progressed to AIDS, the patients were followed in every three months, otherwise, they were followed six monthly. Accordingly, during the follow up period, blood samples for CD4 count and viral load testing were collected in every 3 or 6 months from each patient. The patients were appropriately treated as per the criteria. Treatment was indicated for confirmed sero-positive WHO Stage III or IV clinical HIV cases and those who had any of the following: symptomatic disease, extra-pulmonary tuberculosis (TB), laboratory criteria of CD4 count below 350 cells/l or in the absence of CD4 count results: total lymphocyte count below 1200 cells/l)16. The treatment criteria did change over time. Before 2007, only those PLWHA who had progressed to AIDS and had CD4 count <200 cells/l were considered eligible for treatment. This cut-off for CD4 count c.Diagnosis and the quality of the received treatment14. Hence the dearth of information regarding the determinants of mortality among PLWHA in China called for a detailed retrospective national level investigation to assess the impact of HIV on adult mortality and to identify correlates of total and AIDS-related mortality among adult PLWHA in this country. Our study aimed to evaluate the mortality rate among PLWHA since they were identified/reported and to evaluate the potential correlates of AIDS related and unrelated deaths in this population in China, by analyzing the data from a concurrent cohort study (The National HIV Epidemiology Cohort) which was monitoring mortality among PLWHA in China.MethodThe data used in this current article were obtained from the HIV/AIDS case reporting system (CRS) under the National Center for AIDS/STD Control and Prevention of the Chinese Center for Disease Control and Prevention (China CDC) between 1989 and 2013. The methods were carried out in accordance with the approved guidelines.Recruitment.Detailed information regarding the relevant databases is described elsewhere15. In brief, this retrospective cohort study was based on Chinese HIV/AIDS case report system and treatment database. Any information collected from these two platforms was included in the current study base, while the two systems were linked by a unique personal ID. No additional identification information was collected from the participants. All newly identified HIV cases were reported to the web-based systems either by local hospitals or clinics. Information on demographic characteristics [age, gender, occupation, ethnicity, address, registered place of residency (Hukou) etc.], HIV related risk-behaviors, treatment history, routes of transmission (heterosexual/homosexual/IDU/transfusion of blood or other blood cells) and disease status (HIV/AIDS based on WHO criteria) at the time of diagnosis were also collected from all the registered PLWHA. PLWHA were considered eligible to be recruited for this concurrent cohort study if they were aged 18 years or older and had at least one follow up record since their initial reporting to the national database between January 1, 1989 and June 30, 2012. Frequency of CD4 testing for each participant was also calculated in every six months, and frequency of CD4 testing was defined as the cumulative number of CD4 testing at each year divided by two (every six months).After identification and reporting, all HIV cases were followed up by the local CDCs. The intervals of two follow up varied between three or six months, depending on the disease status. If already been progressed to AIDS, the patients were followed in every three months, otherwise, they were followed six monthly. Accordingly, during the follow up period, blood samples for CD4 count and viral load testing were collected in every 3 or 6 months from each patient. The patients were appropriately treated as per the criteria. Treatment was indicated for confirmed sero-positive WHO Stage III or IV clinical HIV cases and those who had any of the following: symptomatic disease, extra-pulmonary tuberculosis (TB), laboratory criteria of CD4 count below 350 cells/l or in the absence of CD4 count results: total lymphocyte count below 1200 cells/l)16. The treatment criteria did change over time. Before 2007, only those PLWHA who had progressed to AIDS and had CD4 count <200 cells/l were considered eligible for treatment. This cut-off for CD4 count c.
