Ciencewww.frontiersin.orgAugust Volume Report Chechlacz et al.Neuroanatomy of unilateral visual neglectsubstrates of the heterogeneous symptoms linked with unilateral visual neglect.All searches have been carried out using PubMed and Web of Know-how databases.The database searches have been performed making use of the following (visual neglect OR unilateral neglect OR spatial neglect OR line bisection OR target cancelation) AND (anatomy OR neuroanatomy OR tractography OR diffusion tensor imaging OR NSC-281668 Purity & Documentation perfusion weighted imaging OR diffusion weighted imaging OR lesionsymptom mapping OR VBM OR VLSM OR computed tomography OR magnetic resonance imaging).Also, we also identified studies by means of references cited by critique papers and via references from relevant papers located through database searches.The inclusion criteria had been as follows studies published in peerreviewed journals; use of lesionsymptom mapping approaches as defined inside the Introduction, i.e either lesion subtraction solutions (depending on either comparisons between the lesion overlap plots from patients with and without having neglect or formal subtraction plots involving the groups), VBM, or VLSMVLBM strategies; the studied sample consisted of primarily brain injured individuals and each experimental and handle sufferers groups had been describeddefined clearly; the findings had been reported employing spatial coordinates in either Montreal Neurological Institute (MNI; Evans et al) or Talairach space (Talairach and Tournoux,); papers defined neglect determined by widespread assessment tools including at the very least among the following target cancelation, bisection, word reading, and figure copy (see Figure).In instances exactly where normal coordinates were not reported inside the lesionsymptom analyses, we contacted the authors to request this information.If the authors agreed to provide the info, the research have been incorporated in our metaanalyses (we thank the following authors for offering these added information on our request Bird et al Medina et al Eschenbeck et al Karnath et al Vossel et al Saj et al).We excluded studies that were not published in English; reported either preliminary findings or conference presentations; single case studies or multiplecase studies according to sufferers preselected in line with either lesion location or cognitive deficits without the need of comparison to appropriate patient manage groups (research using conventional lesion overlap evaluation determined by overlapping the lesion maps of patients with specific deficit and defining an location of maximum overlap as the brain area critically subserving the cognitive function impaired within the patients); functional neuroimaging research (fMRI, PET, etc) in either sufferers or healthier controls.Following the literature search, we developed lists of reported peak coordinates (foci) for every single individual study entered into our ALE metaanalyses.In Table under Analysis we list the number of all foci as reporteddefined by the authors of every single study based on all relevant analyses on the neuroanatomy of neglect (as an example if authors report both peak coordinates from lesion subtraction and VLSM, all these had been listed).We entered into evaluation all coordinates that were provided by the authors to describe their outcomes, i.e all coordinates listed in text, tables, or figures excluding onlythese that had been repeated for example each in text and tables, and so on.In case PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21524470 of research that do not give a single peak coordinate but border coordinates of maximum overlap for neglect group versus controls (.
