In the amount of indebtedness features a not substantial impact around the size on the after-tax income of profitable firms. 4. Conclusions The aim of this study was to confirm or refute the initial hypothesis, namely that in one of the Visegrad nations or above a specific income category, additional effective management of financial investments (acquisitions, loans) within the pharmaceutical market generates higher profitability on equity. Contrary to expectations, the investigations showed that there was no powerful correlation in between the explanatory variables along with the outcome variable incorporated inside the regression model, neither in the national level nor at the degree of regional marketplace position groups. Considering the fact that statistical partnership is just not detectable between the ROE express-Economies 2021, 9,12 ofing dividend expectations along with the economic revenue per asset indicator, it is actually not common for pharmaceutical providers to create greater threat decisions in the economic investment market so as to attain a greater position in view of equity investors. As a consequence, the extremely higher amount of indirect expense is mostly financed by the management with the pharmaceutical companies, apart from the sales revenue from the successful goods, from monetary revenue. Additionally, as suggested by Malerba and Orsenigo (2015) and Scherer (2000), businesses which might be not indebted to only suppliers are inclined to take on risks associated with larger returns on economic investments, thereby offsetting the good impact from the latter on earnings, which will be reflected inside the regression estimate. Spatial and temporal limitations of your economic 3-Methyl-2-oxovaleric acid site evaluation integrated that the queried corporate database covered only the Visegrad nations using a various variety of market players in each nation, and that only information in the most recently published economic statements had been regarded as inside the study. Moreover, it was a limitation that the statistically exceptionally high ROE worth was driven by persistently adverse management choices rather than profitable operations. Additional investigation of this investigation query is warranted employing newer firm databases, multi-year periodic data, and developing on this, panel regression evaluation methods, which may possibly even modify the above model results. Because it would have already been justified from a management point of view to confirm the initial hypothesis, further investigation around the profitability effect of higher financial risk-taking could also be appropriate by such as time series data also as indicators from Western European and North American pharmaceutical firms.Author Contributions: Conceptualization, G.T., V.L. and B.B.M.; methodology, G.T.; application, G.T.; validation, G.T., V.L. and B.B.M.; formal evaluation, G.T.; investigation, G.T.; resources, G.T., V.L. and B.B.M.; data curation, G.T.; writing–original draft preparation, G.T.; writing–review and editing, V.L.; visualization, G.T. and V.L.; supervision, B.B.M.; project administration, G.T., V.L. and B.B.M.; funding Resazurin Autophagy acquisition, V.L. All authors have study and agreed to the published version with the manuscript. Funding: This paper is supported by EFOP-3.6.3-VEKOP-16-2017-00007–“Young researchers for talent”–supporting careers in analysis activities in higher education program. This project is co-financed by the European Union along with the European Social Fund. Information Availability Statement: The information presented in this study are openly available in the EMIS database. Conflicts of Interest: The authors decla.