Ategic Improvement Fund. Institutional Review Board Statement: Not applicable. Institutional Review Board Statement: Not applicable. Informed SW155246 MedChemExpress Consent Statement: Not applicable. Informed Consent Statement: Not applicable. Information Availability Statement: Not applicable. Data Availability Statement: Not applicable. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.antibioticsArticleAntimicrobial Impact of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control StudyReham AlJasser 1, , Razan AlAqeely 1 , Afnan AlZahrani 2 , Manal AlKenani three , Glyphosate-d2 Technical Information Sadeem AlQahtani three , Mohammed AlSarhan 1 , Dalal AlOtaibi 1 and Rhodanne Lambarte2Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia; [email protected] (R.A.); [email protected] (M.A.); [email protected] (D.A.) Ministry of Well being, Riyadh 11176, Saudi Arabia; afnan36x@gmail Saudi Board of Periodontics, Riyadh 11545, Saudi Arabia; manalkenani95@gmail (M.A.); sadeemsq15@gmail (S.A.) Molecular and Cell Biology Laboratory, Prince Naif Bin AbdulAziz Health Investigation Center, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia; [email protected] Correspondence: [email protected]; Tel.: 966-534-119-Citation: AlJasser, R.; AlAqeely, R.; AlZahrani, A.; AlKenani, M.; AlQahtani, S.; AlSarhan, M.; AlOtaibi, D.; Lambarte, R. Antimicrobial Impact of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study. Antibiotics 2021, ten, 1286. https:// doi.org/10.3390/antibiotics10111286 Academic Editor: Tetsuya Adachi Received: 22 September 2021 Accepted: 13 October 2021 Published: 21 OctoberAbstract: Isotretinoin (INN), a drug applied to treat extreme acne, has anti-inflammatory and antibacterial properties. INN may possibly impact periodontal pathogenic bacteria, so we aimed to study the impact of INN on intraoral microbial profiles of periodontal disease and healthful periodontium. Our case-control study divided 180 subjects into six groups based on periodontal wellness status and INN usage as follows: healthful periodontium getting INN (HINN; n = 30); these with generalized plaque-induced gingivitis receiving INN (GINN; n = 30); and these with stage I generalized periodontitis receiving INN (PINN; n = 30). Subjects not taking INN, have been categorized inside the very same manner: those using a healthful periodontium (HC; n = 30); these with generalized plaque-induced gingivitis (GC; n = 30); and those with generalized periodontitis stage I (Computer; n = 30). Plaque samples have been collected to establish the prevalence of four periodontal pathogens (Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum) in every single study group utilizing real-time polymerase chain reaction. Data have been analyzed making use of IBM SPSS computer software, and several regression evaluation was performed for each parameter tested in every single group at a significance amount of 0.05. All INN groups showed substantially lower levels of P. gingivalis, T. forsythia, and T. denticola and larger levels of F. nucleatum (p 0.001). INN had an observable antimicrobial effect around the periodontal pathogen count in patients with plaque-induced gingivitis and chronic periodontitis. INN could have a possible additive antimicrobial worth inside the treatment of periodontal disease. Keywords and phrases: oral microbes; periodontal pathogens; isotretinoin; periodontal therapyPublisher’s Note: MDPI stays neutr.
