Y to clarify its distinct mechanisms of general anticancer impact inHCC, our results supplied novel evidence on the understanding from the possible targets of SA to inhibit HCC metastasis.Data AVAILABILITY STATEMENTThe datasets generated for this study is often discovered in NCBI BioProject (PRJNA643657).ETHICS STATEMENTThe Animal study was reviewed and authorized by Animal Care and Use Committee of Shanghai University of Medicine Wellness Sciences.AUTHOR CONTRIBUTIONSHW contributed to style of your study. JL, HJ, XW, and YC performed all the experiments. JL, YF, QH and YM processed the experimental data. JL wrote the manuscript. HW, YG, and YS edited the manuscript. All authors study and authorized the submitted version.FUNDINGThe study was funded by National Organic Adenosine A1 receptor (A1R) Antagonist Formulation Science Foundation of China (81903961 to JL, 31671453, 31870905 to HW, 81673938 and 81874436 to YG, 81874377 to YS), the Natural Science Foundation of Shanghai (19ZR1424000) to JL, the Scientific Program of Shanghai Municipal Overall health Commission (SHWJ2019211) to HW, and Building Project of Shanghai Important Laboratory of Molecular Imaging (18DZ2260400) as well as the Essential Program of National Organic Science Foundation of China (81830052).SUPPLEMENTARY MATERIALThe Supplementary Material for this article could be discovered on the internet at: https://www.frontiersin.org/articles/10.3389/fphar.2020.566099/ full#supplementary-material.Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., and Jemal, A. (2018). International cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 39424. doi:10.3322/caac.21492 Cao, Y., Xia, Q. H., Meng, H., and Zhong, A. P. (2005). Adenosine A3 receptor (A3R) Agonist Formulation Antitumor and synergistic effect of Chinese medicine “bushen huayu jiedu recipe” and chemotherapy on transplanted animal hepatocarcinoma. Planet J. Gastroenterol 11, 5218220. doi:10.3748/wjg.v11.i33.5218 Cha, T. L., Qiu, L., Chen, C. T., Wen, Y., and Hung, M. C. (2005). Emodin downregulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res. 65, 2287295. doi:ten.1158/0008-5472.CAN-04-3250 Chen, G., and Goeddel, D. V. (2002). TNF-R1 signaling: a gorgeous pathway. Science 296, 1634635. doi:10.1126/science.
Open accessOriginal researchCross-sectional and prospective relationships of endogenous progestogens and estrogens with glucose metabolism in guys and ladies: a KORA F4/FF4 StudyLina Hui Ying Lau ,1,two,three Jana Nano,1,four Alexander Cecil ,5 1 four,6 Florian Schederecker , Wolfgang Rathmann , Cornelia Prehn 7,8 9 , Jerzy Adamski ,five,ten,11 Tanja Zeller, Andreas Lechner 1,4 Annette Peters ,1,4,12 Barbara Thorand ,To cite: Lau LHY, Nano J, Cecil A, et al. Cross-sectional and prospective relationships of endogenous progestogens and estrogens with glucose metabolism in men and females: a KORA F4/FF4 Study. BMJ Open Diab Res Care 2021;9:e001951. doi:ten.1136/ bmjdrc-2020-001951 Supplemental material is published online only. To view, please take a look at the journal online (http://dx.doi.org/10.1136/ bmjdrc-2020-001951).ABSTRACTReceived 15 October 2020 Revised three January 2021 Accepted 9 JanuaryAuthor(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. For numbered affiliations see end of report. Correspondence to Professor Barbara Thorand; thorand@helmholtz-muenchen. deIntroduction Relationships among endogenous female sex hormones and glycemic traits remain understudied, particularly in males. We examined no matter whether endogenous 17-hydroxyprogesterone (17-OHP.
