] [SCI Expanded] [ISI Alerting System] [ISI Journals Master List] [Index Medicus
] [SCI Expanded] [ISI Alerting System] [ISI Journals Master List] [Index Medicus/MEDLINE] [EMBASE/Excerpta Medica] [Chemical Abstracts/CAS]Lan X. et al: VPA-Na concentrations in epilepsy Med Sci Monit, 2021; 27: eCLINICAL RESEARCHTable 1. Demographic characteristic of sufferers. Item Sex (F/M) Age (years) 0-13 14-60 0 18 17 21 five 24 22 Normal concentration group (n=56) 44/12 Substandard concentration group (n=51) 38/Table two. Chi-squared test of standard-reaching price of VPA serum concentrations by single-factor analysis. Variable Age/years 3 14-59 0 Sex Male Female Daily dose .five 0.5-1 1 Dosage type Non-sustained release dosage form Sustained-release dosage type Hepatic function Regular or mild injury Severe injury Renal function Normal or mild injury Moderate to serious Carbapenems No Combination Enzyme PPAR Agonist Synonyms inducer drugs No Combination n (Regular concentration) 18 17 21 44 12 18 26 12 45 11 three 53 5 51 55 1 52 4 n (Substandard concentration) five 24 22 38 13 ten 37 4 44 7 two 49 ten 41 34 17 33 18 ( of all) 78.3 41.five 48.8 53.7 48 64.three 41.three 75 50.6 61.1 60 52 33.3 55.4 61.8 5.6 61.18 18.18 0.01 0.0001 0.1120 1.000 0.414 0.020 0.620 P 0.of 56 sufferers (51.38 ) was within the reference variety; the serum drug concentration of 51 sufferers (46.79 ) was under the decrease limit of your reference value; along with the remaining two sufferers had serum concentrations above the upper limit of the reference worth (Table 1). Clinical Information Initially, we carried out MMP-13 Inhibitor Accession univariate analysis. To facilitate the discussion and correct conclusions, the information of your two patients exceeding the upper limit in the reference value had been eliminated,as well as the chi-squared test was utilized to calculate the difference from the standard-reaching price under the influence of a single factor. The chi-squared test outcomes showed no substantial differences in the standard-reaching price of serum drug concentrations in groups divided by sex, dosage form, liver function, kidney function, and combined enzyme inducer. Having said that, there had been substantial differences inside the standard-reaching rate of serum drug concentration in other groups, including the juvenile and high-dose groups. The standard-reaching price inside the juvenile group was higher than that within the mature group and elderly group; the rate was decrease within the low-dose group andThis operate is licensed beneath Creative Common AttributionNonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)e934275-Indexed in: [Current Contents/Clinical Medicine] [SCI Expanded] [ISI Alerting System] [ISI Journals Master List] [Index Medicus/MEDLINE] [EMBASE/Excerpta Medica] [Chemical Abstracts/CAS]CLINICAL RESEARCHLan X. et al: VPA-Na concentrations in epilepsy Med Sci Monit, 2021; 27: eTable 3. Outcome of multi-logistic regression analysis for VPA serum concentration reduce than the regular. b Carbapenems Enzyme inducer drugs three.62 1.36 SE 1.08 0.55 Wald 11.34 six.11 P 0.001 0.intermediate-dose group than in the high-dose group; and within the group getting carbapenems in mixture, the standard-reaching price was decrease than that in the non-combination group (Table two). The second a part of the study applied various logistic regression to analyze VPA-Na serum concentrations reduce than the regular. As outlined by the outcomes on the influence of a single issue and after excluding the data of your two sufferers whose concentrations exceeded the upper limit with the reference worth, the variables described above were analyzed by binary logistic regression. We showed that the combination.
