390/molecules26195757 Academic Editor: Raffaele Pezzani Received: 21 August 2021 Accepted: 16 September 2021 Published: 23 September10 9Department of Medicinal Chemist and Pharmacognosy, College of STAT3 Source Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] Division of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo 11371, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] (S.A.A.M.); [email protected] (M.S.M.S.) Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, JUST, Irbid 22110, Jordan Hospital of Police Academy, Nasr city, Cairo 11765, Egypt; mohamedshawky1974@yahoo Division of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt; [email protected] Department of Pharmaceutics, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] Department of Clinical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Abdia, Makkah 21955, Saudi Arabia; [email protected] (S.Y.E.); [email protected] (M.Z.E.-R.) Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; [email protected] Correspondence: [email protected] (H.A.M.); [email protected] (H.M.E.); [email protected] (R.A.K.); Tel.: +00966566176074 (H.A.M.)Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This short article is definitely an open access short article distributed below the terms and situations of your Inventive Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ 4.0/).Abstract: Sage, Salvia officinalis L., is utilized worldwide as an aromatic herb for culinary purposes also as a regular medicinal agent for many ailments. Current investigations exhibited the effects of extended dryings from the herb on the yields, composition, oil excellent, and hepatoprotective as well as anti-cancer biological activities in the hydrodistillation-α4β7 custom synthesis obtained necessary oils from the aerial parts of your plant. The crucial oils’ yields, compositions, and biological activities levels on the fresh and differently timed and room-temperature dried herbs differed substantially. The lowest yields on the necessary oil had been obtained from the fresh herbs (FH, 631 mg, 0.16 ), although the highest yield was obtained from the two-week dried herbs (2WDH, 1102 mg, 0.28 ). A notable decrease in monoterpenes, with increment in the sesquiterpene constituents, was observed for the FH-based vital oil as in comparison with each of the other batches on the essential oils obtained from the differenttimed dried herbs. Additionally, characteristic chemotypic constituents of sage, i.e., -pinene, camphene, -pinene, myrcene, 1, 8-cineole, -thujone, and camphor, have been present in considerably greater proportions in each of the dried herbs’ crucial oils as in comparison with the FH-based critical oil. The in vivo hepatoprotective activity demonstrated significant reductions within the levels of AST, ALT, and ALP, too as a substantial increase inside the total protein (p 0.05) contents level, as compared to the acetaminophen (AAP) administered experimental group of rats. A significant reduction (p 0.05) within the ALT level was demonstrated by the 4W
