. Purcell AW, Elliott T. Molecular machinations on the MHC-I peptide loading
. Purcell AW, Elliott T. Molecular machinations on the MHC-I peptide loading complex. Curr Opin Immunol. 2008;20(1):751. Thirdborough SM, Roddick JS, ALK7 Formulation Radcliffe JN, Howarth M, Stevenson FK, Elliott T. Tapasin shapes immunodominance hierarchies in line with the kinetic stability of peptide-MHC class I complexes. Eur J Immunol. 2008;38(two):364. Boulanger DS, Oliveira R, Ayers L, Prior SH, James E, Williams AP, et al. Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope. J Immunol. 2010;184(1):733. Chen X, Lai J, Pan Q , Tang Z, Yu Y, Zang G. The delivery of HBcAg by way of Tat-PTD enhances distinct immune response and inhibits Hepatitis B virus replication in transgenic mice. Vaccine. 2010;28(23):3913. Chen X, Liu H, Tang Z, Yu Y, Zang G. The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes by way of cytoplasmic transduction peptide. Acta Biochim Biophys Sin (Shanghai). 2013;45(three):2032. Krachler AM, Woolery AR, Orth K. Manipulation of kinase signaling by bacterial pathogens. J Cell Biol. 2011;195(7):10832. Sullivan JA, Kim EH, Plisch EH, Suresh M. FOXO3 regulates the CD8 T cell response to a D3 Receptor Source chronic viral infection. J Virol. 2012;86(17):90254. Cai N, Dai SD, Liu NN, Liu LM, Zhao N, Chen L. PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells. Int J Ophthalmol. 2012;5(six):6750. Surviladze Z, Sterk RT, DeHaro SA, Ozbun MA. Cellular entry of human papillomavirus sort 16 requires activation from the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy. J Virol. 2013;87(five):25087. Harriague J, Bismuth G. Imaging antigen-induced PI3K activation in T cells. Nat Immunol. 2002;three(11):1090. Rubinstein MP, Lind NA, Purton JF, Filippou P, Most effective JA, McGhee PA, et al. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets for the duration of contraction from the immune response. Blood. 2008;112(9):37042. Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell. 2009;138(1):300. Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, et al. Regulatory T cells contribute towards the impaired immune response in individuals with chronic hepatitis B virus infection. Hepatology. 2005;41(4):771. Woltman AM, Op den Brouw ML, Biesta PJ, Shi CC, Janssen HL. Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function. PLoS A single. 2011;six(1): ee15324 Tsai SL, Sheen IS, Chien RN, Chu CM, Huang HC, Chuang YL, et al. Activation of Th1 immunity is a typical immune mechanism for the prosperous treatment of hepatitis B and C: tetramer assay and therapeutic implications. J Biomed Sci. 2003;10(1):1205. Chen M, Bouvier M. Analysis of interactions inside a tapasin/class8. 9.10. 11. 12. 13.AcknowledgementsYong-Sheng Yu, Xiao-Hua Chen, and Yu-Yan Tang had the original concept for the study, made the study protocol, and wrote the paper. Yi Zhang, Meng Zhuo, and Yu-Yan Tang performed the experiments. Zheng-Hao Tang and Guo-Qing Zang analyzed the data. Yong-Sheng Yu, Xiao-Hua Chen, Yu-Yan Tang, Zheng-Hao Tang, and Guo-Qing Zang wrote the final version of your paper. All authors reviewed and authorized the final draft from the paper. All authors have no monetary interests connected to the material within the manuscript. This study was supported by grants in the National All-natural Science Foundation of China (No. 31000414 and No. 81070335).Authors’ Contribution14. 15. 16. 17.Financial D.