137 http://www.molecular-cancer/content/12/1/Page 19 ofAuthor facts 1 Division of Oncology, University of Torino, by means of Santena 5/bis, 10126 Torino, Italy. 2Department of Pharmacological and Biomolecular Sciences, University of Milano, by way of Trentacoste 2, 20134 Milan, Italy. 3Center for Experimental Research and Healthcare Studies, University of Torino, by means of Santena 5/bis, 10126 Torino, Italy. Received: 13 August 2013 Accepted: 11 November 2013 Published: 13 NovemberReferences 1. Chang CL, Deckelbaum RJ: Omega-3 fatty acids: mechanisms underlying `protective effects’ in atherosclerosis. Curr Opin Lipidol 2013, 24:34550. 2. Maskrey BH, Megson IL, Rossi AG, Whitfield PD: Emerging significance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic approaches for their analysis. Mol Nutr Food Res 2013, 57:1390400. three. Laviano A, Rianda S, Molfino A, Rossi Fanelli F: Omega-3 fatty acids in cancer. Curr Opin Clin Nutr Metab Care 2013, 16:15661. four. Dewell A, Marvasti FF, Harris WS, Tsao P, Gardner CD: Low- and high-dose plant and marine (n-3) fatty acids do not have an effect on plasma inflammatory markers in adults with metabolic syndrome. J Nutr 2011, 141:2166171. 5. Jeckel KM, Veeramachaneni DN, Chicco AJ, Chapman PL, Mulligan CM, Hegarty JR, Pagliassotti MJ, Ferguson LA, Bouma GJ, Frye MA: Docosahexaenoic acid supplementation doesn’t enhance western diet-induced cardiomyopathy in rats. PLoS 1 2012, 7:e51994. 6. Galvao TF, Khairallah RJ, Dabkowski ER, Brown BH, Hecker PA, O’Connell KA, O’Shea KM, Sabbah HN, Rastogi S, Daneault C, Des Rosiers C, Stanley WC: Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but usually do not increase survival. Am J Physiol Heart Circ Physiol 2013, 304:H12 21. 7. Brasky TM, Darke AK, Song X, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr, Goodman GE, Minasian LM, Parnes HL, Klein EA, Kristal AR: Plasma phospholipid fatty acids and prostate cancer threat within the Select trial. J Natl Cancer Inst 2013, 105:1132141. eight. Chua ME, Sio MC, Sorongon MC, Morales ML Jr: The relevance of serum levels of extended chain omega-3 polyunsaturated fatty acids and prostate cancer risk: a meta-analysis.(2-Bromophenyl)boronic acid Epigenetics Can Urol Assoc J 2013, 7:E333 343.Annexin V-FITC/PI Apoptosis Detection Kit custom synthesis 9.PMID:24982871 Sorongon-Legaspi MK, Chua M, Sio MC, Morales M Jr: Blood level omega-3 fatty acids as danger determinant molecular biomarker for prostate cancer. Prostate Cancer 2013, 2013:e875615. ten. Alexander W: Prostate cancer risk and omega-3 fatty acid intake from fish oil. PT 2013, 38:56164. 11. Geelen A, Schouten JM, Kamphuis C, Stam BE, Burema J, Renkema JM, Bakker EJ, van’t Veer P, Kampman E: Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort research. Am J Epidemiol 2007, 166:1116125. 12. Fini L, Piazzi G, Ceccarelli C, Daoud Y, Belluzzi A, Munarini A, Graziani G, Fogliano V, Selgrad M, Garcia M, Gasbarrini A, Genta RM, Boland CR, Ricciardiello L: Extremely purified eicosapentaenoic acid as totally free fatty acids strongly suppresses polyps in Apc(Min/+) mice. Clin Cancer Res 2010, 16:5703711. 13. Courtney ED, Matthews S, Finlayson C, Di Pierro D, Belluzzi A, Roda E, Kang JY, Leicester RJ: Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in regular colonic mucosa in subjects having a history of colorectal adenomas. Int J Colorectal Dis 2007, 22:76576. 14. HofmanovJ, VaculovA, Kozub A: Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells.