Product Name :
AdipoRon hydrochloride
Description:
AdipoRon hydrochloride is an orally active and specific AdipoR agonist, binding to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM, respectively.
CAS:
1781835-20-8
Molecular Weight:
464.98
Formula:
C27H29ClN2O3
Chemical Name:
2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide hydrochloride
Smiles :
Cl.O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1
InChiKey:
TZVJQEGKRLDTHQ-UHFFFAOYSA-N
InChi :
InChI=1S/C27H28N2O3.ClH/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22;/h1-14,24H,15-20H2,(H,28,30);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AdipoRon hydrochloride is an orally active and specific AdipoR agonist, binding to AdipoR1 and AdipoR2, with Kds of 1.{{ATP} web|{ATP} Metabolic Enzyme/Protease|{ATP} Technical Information|{ATP} In Vivo|{ATP} manufacturer|{ATP} Epigenetic Reader Domain} 8 and 3.1 μM, respectively.|Product information|CAS Number: 1781835-20-8|Molecular Weight: 464.98|Formula: C27H29ClN2O3|Chemical Name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide hydrochloride|Smiles: Cl.O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1|InChiKey: TZVJQEGKRLDTHQ-UHFFFAOYSA-N|InChi: InChI=1S/C27H28N2O3.ClH/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22;/h1-14,24H,15-20H2,(H,28,30);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Apraglutide} medchemexpress|{Apraglutide} GPCR/G Protein|{Apraglutide} Purity & Documentation|{Apraglutide} References|{Apraglutide} custom synthesis|{Apraglutide} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23991096 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AdipoRon hydrochloride is an orally active and specific AdipoR agonist, binds to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM. AdipoRon (50 nM-50 μM) increases AMPK phosphorylation via AdipoR1. AdipoRon (50 μM) dose-dependently attenuates the expression of TNF-α and TGF-β1 in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages. AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis. AdipoRon exerts vasodilation by mechanisms distinct to adiponectin and induces vasorelaxation without a marked decrease in VSMC [Ca2+]i.|In Vivo:|AdipoRon (50 mg/kg, i.v.) cuases significant phosphorylation of AMPK in skeletal muscle and liver of wild-type mice but not Adipor1−/− Adipor2−/− double-knockout mice. AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice, and prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg). Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice.|Products are for research use only. Not for human use.|
